| Pair Name | Andrographolide, Fluorouracil | ||
| Phytochemical Name | Andrographolide (PubChem CID: 5318517 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Andrographolide, Fluorouracil | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Gene Regulation | Up-regulation | Expression | CYP1A2 | hsa1544 |
| Up-regulation | Expression | CYP3A4 | hsa1576 | |
| Down-regulation | Expression | CYP2D6 | hsa1565 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| Result | Interactive effects of Andrographis paniculata extracts and cancer chemotherapeutic 5-Fluorouracil on cytochrome P450s expression in human hepatocellular carcinoma HepG2 cells | |||
| Pair Name | Andrographolide, Fluorouracil | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | DKK1 | hsa22943 | |
| Result | Our data provide novel evidence for andrographis-mediated reversal of 5FU resistance, highlighting its potential role as an adjunct to conventional chemotherapy in CRC. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Interactive effects of Andrographis paniculata extracts and cancer chemotherapeutic 5-Fluorouracil on cytochrome P450s expression in human hepatocellular carcinoma HepG2 cells | Click |
| 2 | Andrographis overcomes 5-fluorouracil-associated chemoresistance through inhibition of DKK1 in colorectal cancer. Carcinogenesis. 2021 Jun 21;42(6):814-825. doi: 10.1093/carcin/bgab027. | Click |
